Treatments for knee osteoarthritis are ranked for impact on pain and function

Share Button

naproxen, knee pain, knee arthritis, arthritis treatment, arthritis drug, arthritis digest magazineThe effectiveness of non-surgical treatments for knee osteoarthritis have been ranked in the US and naproxen comes out top.

Data from multiple trials was analysed and treatments compared and ranked. These included acetaminophen, ibuprofen, intra-articular or joint injections of cortisone, platelet-rich plasma, hyaluronic acid, several NSAIDs (such as naproxen, celecoxib and diclofenac) and oral and intra-articular placebo.

Key findings

  • For pain reduction, cortisone injections provided the greatest short-term (4 to 6 weeks) pain relief, followed by ibuprofen, platelet-rich plasma injections, naproxen and celecoxib;
  • For improving function, naproxen ranked the highest for improving function, followed by diclofenac, celecoxib, ibuprofen and platelet-rich plasma injections;
  • For improving both pain and function, naproxen was ranked the most effective, followed by cortisone injections, platelet-rich plasma injections, ibuprofen and celecoxib;
  • Hyaluronic acid injections did not achieve a rank in the top five treatments for pain, function, or combined pain and function.

We know that NSAIDs have potential risks, including heart attack and stroke, but the evidence suggests that naproxen has less potential for adverse cardiovascular events.

“This is the first comprehensive mixed-comparison analysis comparing best-evidence scientific research and excluding lower quality studies that can bias the outcomes,” explains lead author Dr David Jevsevar. “Using a statistical ranking technique, we worked to provide evidence regarding which of the most common NSAIDs are most likely to decrease pain and improve function, and we attempted to fill in the gaps in evidence for more inconclusive treatments such as hyaluronic acid, platelet rich plasma and corticosteroids.”

For more in-depth features, interviews and information, subscribe to Arthritis Digest magazine, a popular title that’s published six times a year. Click here for the digital version or tel 0845 643 8470 to order your had copy. You’ll know what your doctor is talking about, what new drugs are in the pipeline and be up to date on helpful products.

“Amazing magazine and the first I’ve read from beginning to end.” Mrs E Crowther, Dorset

“There’s so much news and information to digest, and it’s all calorie free. Brilliant!” A Alexander, Glasgow
“As we are all living longer, it gives us hope for a future with less pain. Arthritis Digest gives us information on the up to date treatments.”Mrs Healey, Devon
“Full of interesting information and tips.” Mr G Thurlow, East Yorkshire

Google+ | Privacy Policy | FTC Disclaimer

Copyright © 2013. All Rights Reserved.