Combination of drugs may slow spine damage in ankylosing spondylitis – new findings

A combination of nonsteroidal anti-inflammatory drugs (NSAIDs) and TNF-inhibitors may help slow down spine damage in ankylosing spondylitis, experts report at the American College of Rheumatology Annual Scientific Meeting.Recent research on the effectiveness of NSAIDs and TNF-inhibitors on people with inflammatory arthritis has been mixed, so a team conducted a study to look at the effects of a combination of the two options on radiographic (X-ray) progression of ankylosing spondylitis.

A total of 527 people with ankylosing spondylitis (76% men, average age 43 years, average disease duration 18 years) were followed for over three years. Of the participants, 78% used NSAIDs and 58% used TNF-inhibitors.

Results

There was significant interaction between TNF-inhibitors and NSAIDs. When TNF-inhibitors were used with higher doses of NSAIDs, participants had a 70% reduction in radiographic progression.

“This is the first study to show this relationship and potentially sheds light on why prior study results have been so controversial,” explains Dr Lianne Gensler, who led the work. “I think it is important to remember that despite the results, not every patient will progress or warrant this kind of regimen. That said, for those with greater risk, this combination may be especially helpful.”

For more in-depth features, interviews and information, subscribe to Arthritis Digest magazine, a popular title that’s published six times a year. Click here for the digital version or tel 0845 643 8470 to order your had copy. You’ll know what your doctor is talking about, what new drugs are in the pipeline and be up to date on helpful products.