Anti-nerve growth factor antibodies may relieve osteoarthritis pain and improve function

Blocking nerve growth factor (NGF) with antibodies is a promising strategy for treatment of chronic pain associated with osteoarthritis (OA). Studies have looked at if anti-NGF antibodies can work on osteoarthritis pain and chronic low-back pain, and a group of researchers decided to analyse them to see what trends emerged, reporting their findings in Current Rheumatology Reports.

The work shows anti-NGF antibodies did reduce pain scores and increase physical function. The two drugs in development, tanuzemab and fasinumab, are performing well in trials but are not yet available to patients.

The research group concludes that: “anti-NGF antibodies can relieve pain and improve function in patients with osteoarthritis pain and chronic low-back pain.”

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