Human-derived cartilage cells are printed, implanted and induced to grow – groundbreaking research

3D-bioprinted cartilage cells have been successfully implanted in an exciting new study, scientists report in Plastic and Reconstructive Surgery Global Open. The research represents a step towards making it possible to repair damage to cartilage seen in osteoarthritis.A hydrogel made from nanocellulose and alginate mixed with human-derived cartilage cells and mesenchymal stem cells was printed using a 3D bioprinter and implanted into mice.

The cartilage tissue was able to carry on growing, and the implants grew more cartilage in the presence of stem cells compared to when the cartilage cells were grown alone. New blood vessels also formed.

After 60 days, white tissue resembling normal human cartilage was formed and worked in the way that would be expected.

Implications

This method could make it possible to create cartilage implants for the treatment of conditions such as arthritis.

Prof Paul Gatenholm, who is involved in the research, comments:

“With what we have done, the research has taken a step forward towards someday, we hope, being able to bioprint cells that become body parts for patients.

“This is how you have to work when it comes to this kind of pioneering activity: one small step at a time. Our results are not a revolution – but they are a gratifying part of an evolution.”

For more in-depth features, interviews and information, subscribe to Arthritis Digest magazine, a popular title that’s published six times a year. Click here for the digital version or tel 0845 643 8470 to order your had copy. You’ll know what your doctor is talking about, what new drugs are in the pipeline and be up to date on helpful products.