Low folic acid limits methotrexate success in rheumatoid arthritis

People with rheumatoid arthritis who have lower levels of folic acid may have less successful outcomes when they’re taking methotrexate, says research published in Arthritis and Rheumatism.

Folic acid is usually taken with methotrexate to reduce side-effects such as nausea. But now a study of nearly 400 people has found that when people take lower levels of folic acid, the effectiveness of methotrexate is limited.

The study has implications for future dosage levels of folic acid. It also suggests that measuring levels of folic acid could be used to predict how people will respond to methotrexate. People with rheumatoid arthritis should receive more personalised treatment plans in the future.

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