Osteoarthritis and metabolism – link discovered

Osteoarthritis could be avoided with a good diet and regular exercise, claims a new review published in Nature Reviews Rheumatology.

Experts have discovered a crucial link between osteoarthritis and metabolism, whereby metabolic changes caused by a sedentary lifestyle and poor diet, trigger the genetic reprogramming of cells in the body and joints. These changes impact on the ability of the cells to produce energy, forcing it to generate alternative sources to function.

The stress this places on cells leads to the overproduction of glucose. When glucose is not used for energy it turns into lactic acid, which is difficult for the body to flush out. High levels of lactic acid in the body leads to inflammation of the cartilage in the joints, which obstructs movement and causes pain.

“For too long osteoarthritis has been known as the ‘wear and tear disease’ and it has been assumed that it is part and parcel of getting older,” says lead author Prof Ali Mobasheri. “However, this is not the case and what we have learnt is that we can control and prevent the onset of this painful condition.

“It is important never to underestimate the significance of a healthy diet and lifestyle as not only does it impact upon our general wellbeing but can alter the metabolic behaviour of our cells, tissues and organs leading to serious illnesses.”

A total of 8.75million people in the UK seek medical advice for osteoarthritis. There is currently no cure and no effective treatment for the painful condition.

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